Pharmaceuticals
AstraZeneca and Ionis's eplontersen failed the CARDIO-TTRansform Phase 3 trial in ATTR-CM. The result reveals a deeper challenge: what happens when the standard of care evolves faster than the trial designed to test against it.
Biotechnology
The FDA approved Trutakna (atacicept) for IgA nephropathy on July 7, 2026, making it the first BAFF/APRIL dual inhibitor cleared for the disease. Here is what the approval means for patients, the competitive landscape, and the science of kidney disease.
Biotechnology
The FDA's expansion of Casgevy to children as young as 2 years old marks a milestone for CRISPR gene therapy, but significant access barriers remain a critical challenge for families.
Biotechnology
For five years, the KRAS G12C inhibitor market in lung cancer has been a story of scientific triumph and commercial disappointment. Amgen's Lumakras and Bristol Myers Squibb's Krazati were genuine breakthroughs when they launched in 2021 and 2022, respectively. They proved that KRAS, long considered undruggable,
Biotechnology
On July 29, an FDA advisory committee will evaluate deramiocel, Capricor's allogeneic cell therapy for Duchenne muscular dystrophy cardiomyopathy. If approved, it would be the first cell-based therapy targeting DMD cardiac dysfunction.
Biotechnology
Anthropic's announcement of Claude Science and its internal drug discovery program signals a major shift in how AI companies are approaching the life sciences—and what it means for pharmaceutical companies.
Biotechnology
Abivax's obefazimod showed impressive efficacy for ulcerative colitis but triggered investor panic over cancer signals. The June 29 data clarified the picture, revealing cancer rates consistent with disease background. Here's what the science actually shows.
Biotechnology
Ipsen's $1.75 billion acquisition of Kartos Therapeutics brings navtemadlin, a novel MDM2 inhibitor, to myelofibrosis patients who have failed ruxolitinib. The drug targets a complementary pathway with promising Phase 1b/2 data showing disease modification signals.
Biotechnology
Viridian Therapeutics' Lumvoa becomes the second FDA-approved treatment for thyroid eye disease, offering new hope for patients with both active and chronic TED.
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The FDA's approval of Ionis's Tryngolza for severe hypertriglyceridemia marks a pivotal moment for RNA medicine, expanding the drug's reach to three million Americans and signaling that RNA-targeting therapies can compete in large, prevalent disease populations.
A clinical trial about to begin in the DRC will test the first antivirals against Bundibugyo ebolavirus in a randomized controlled trial. What happens over the coming weeks will matter far beyond the outbreak itself.
China's approval of CARsgen's satri-cel marks the world's first CAR-T therapy for solid tumors. Here's what it means for the future of cellular immunotherapy and the long-standing barrier between engineered T cells and solid tumor oncology.
Definium's Phase 3 trial shows DT120, an LSD-based treatment, produced an 8.1-point placebo-adjusted improvement in depression symptoms at six weeks with effects visible within the first week.
Nuvectis Pharma (NASDAQ: NVCT) just joined Lilly, AbbVie, and Merck as a Haisco in-licensor, acquiring ex-China rights to two late-stage assets for $40M upfront and up to $1.42B in milestones - a PNH drug with 7x superiority over Soliris in Phase 3, and a next-gen BRAF inhibitor for $20B+ markets.
AbbVie's $10.9 billion acquisition of Apogee Therapeutics signals a strategic shift in immunology drug development. The deal centers on zumilokibart, a long-acting IL-13 inhibitor designed to compete with Dupixent through superior dosing convenience.
On June 18, 2026, an FDA panel voted unanimously to advance Moderna's mRNA flu vaccine, mFlusiva. But the real story isn't the vote—it's the extraordinary regulatory turmoil that preceded it, and what it reveals about vaccine policy in America.
F2G and Shionogi announce positive phase 3 data for olorofim, the first new antifungal class in over two decades, showing non-inferiority to AmBisome in treating invasive aspergillosis.
Rhythm’s latest rare-obesity win strengthens the MC4R thesis - making Palatin’s more selective, next-generation approach one of the small-cap biotech stories to watch
Takeda's oveporexton represents the first direct restoration of orexin signaling in narcolepsy type 1, addressing the root cause rather than managing symptoms. Phase 3 data show improvements in functioning, cognition, and sleep architecture approaching normative levels.
Intellia's lonvo-z CRISPR therapy delivered Phase 3 data showing 87% reduction in HAE attacks and 51% of patients attack-free at six months. If approved, it would be the first in vivo CRISPR therapy cleared by the FDA, and the implications extend far beyond hereditary angioedema.
Sanofi's Tzield becomes the first disease-modifying therapy approved for children with stage 3 type 1 diabetes, marking a historic shift from managing symptoms to treating the underlying disease.
